Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas.
However, a breakdown in the mucosal barrier against gastric acid is not the only mechanism contributing to mucosal injury during NSAIDs administration. National Center for Biotechnology InformationU. Fresh stem bark of C. Preparations of Crossopteryx febrifuga Afzel. Previous studies have shown that some tannins Salawu et al. Oxygen free radicals and lipid peroxidation Takeuchi et al. Adv Prostaglandin Thromboxane Leukot Res. Factors that may contribute to the protection of mucosa, such as mucus and bicarbonate secretion are dependent on gastric blood flow Guth et al.
Drugs that are effective against peptic ulcer act either by reducing the aggressive factors on the gastro-duodenal mucosa or by increasing mucosal resistance against them Larach and Malagelada,Salawu et al. One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia.
Piroxicam caused extensive mucosal atrophy, infiltration by eosinophils and lymphoplasma cells of the wall. Preventive ratio PR defined as the degree of protection offered by a treatment against ulcer causing agent was calculated using the formula:. However in African countries including Nigeria, indigenous herbal medicines are widely used for the management of painful inflammatory disorders, despite an apparent lack of scientific evidence for their quality, safety and efficacy Fennell et al.
Shows ulceration of mucosa layer of group treated with ethanol only Magnification X These rats were approved for use by the AFC committee after reviewing the protocol.
A severe decrease in gastric mucosal blood flow has been reported after treatment with indomethacin Murai et al.
Gastro-Protective Effect of Crossopteryx Febrifuga in Wistar Rats
Thus, illustrating the pharmacodynamic safety of the extract even in painful conditions associated with gastro-intestinal ulceration. The choice of models used for antiulcer evaluation is very appropriate because the protocols undertaken in the rats are those crosssopteryx used for the evaluation of antiulcer agents and are reproducible.
Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats. The ulcer lesions were scored according to severity Larach and Malagelada, as follows: Extensive mucosal atrophy noted, moderate infiltration by eosinophils and lymphoplasma cells of the wall. Ethanol-induced gastric ulceration The method described by Salawu et al. Graph pad prism version 5.
The differences between means of the treated and the control groups were compared using One way analysis of variance ANOVA followed by Dunnet’s post hoc test.
West African Plants
The stomachs were removed, opened along the greater curvature, rinsed with slow running water. Triterpene saponins with gastroprotective effects from tea seed the seeds crlssopteryx Camellia sinensis J Natural Products. Several areas of glandular destruction. Table 3 Crossoptfryx of Histopathology examinations. Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia. The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.
Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. In addition the observed gastro-protective effect of the extract may be related to effects of several classes of active secondary compounds present in this medicinal plant.
The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar. Evidence for protective and antioxidant properties of rutin, crlssopteryx natural flavone, against ethanol induced gastric lesions. Afr J Pharm Pharmacol. The data obtained in the test for acute toxicity suggest that the extract is moderately toxic Salawu et al.
The technical assistance of the Staff of Animal Facility center is highly appreciated. Considering its widespread use in traditional medicine for the management of pain and inflammatory disorders such as arthritis, the need to investigate its safety on the gastrointestinal tract cannot be over emphasized. In the stomach, prostaglandins is critical for the maintenance of gastric mucosal integrity, but the mechanism involved in the cytoprotective action of prostaglandins is still incompletely understood.
Acute toxicity LD50 study The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications. Statistical Analysis Graph pad prism version 5.
Ethanol retards gastric epithelial restoration in monolayer cultures. The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications.
Pharmacological screening and toxicology. Previous studies using crude methanolic extract of C. Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective drugs. Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats.
Oxygen free radical and lipid peroxidation in the pathogenesis crossopteryc gastric mucosal lesions induced by indomethacin in rats. The efficacy of the gastro-histoprotective febrifjga of methanolic extract of Crossopteryx febrifuga against the piroxicam – induced gastric mucosa atrophy and ethanol-induced focal infiltration of inflammatory cells into mucosa areas, were comparable to that of misoprostol and cimetidine respectively.